在唾液中测得的内源性单胺氧化酶A抑制活性（刺蒺藜素）与正常个体的心血管反应性相关。

Endogenous monoamine oxidase A inhibitory activity (tribulin), measured in saliva, is related to cardiovascular reactivity in normal individuals.

作者信息

Clow A, Doyle A, Hucklebridge F, Carroll D, Ring C, Shrimpton J, Willemsen G, Evans P D

机构信息

Psychophysiology and Stress Research Group, University of Westminster, London, United Kingdom.

出版信息

J Neural Transm Suppl. 1998;52:71-7. doi: 10.1007/978-3-7091-6499-0_8.

DOI:10.1007/978-3-7091-6499-0_8

PMID:9564609

Abstract

Salivary monoamine oxidase A inhibitory activity (MAO-AI), mean arterial blood pressure (MAP) and heart rate (HR) were determined simultaneously in healthy male students (n = 13) at rest, before a mild psychological stressor, twice during the task and 18 minutes after the end of the task. The sample as a whole showed significant differences in MAP and HR across occasions (respectively, p < 0.001 for both). Salivary MAO-AI could distinguish novice and experienced game players (p < 0.02) and was consistently positively correlated with MAP (r = 0.58, p < 0.05 on occasion 2). Pre-task measures of MAO-AI for an increased sample (n = 18) were associated with higher MAP (but not HR) throughout the experiment (p < 0.05). Those subject with falling MAO-AI profiles from task to recovery showed significantly greater simultaneous decline in HR than those with a rising MAO-AI profile (p < 0.05).

摘要

在健康男性学生（n = 13）休息时、轻度心理应激源刺激前、任务进行期间两次以及任务结束后18分钟，同时测定唾液单胺氧化酶A抑制活性（MAO - AI）、平均动脉血压（MAP）和心率（HR）。总体样本在不同时间点的MAP和HR存在显著差异（两者均p < 0.001）。唾液MAO - AI能够区分新手和经验丰富的游戏玩家（p < 0.02），并且与MAP始终呈正相关（r = 0.58，在第2次测量时p < 0.05）。增加样本量（n = 18）后，任务前MAO - AI的测量值在整个实验过程中与较高的MAP相关（但与HR无关）（p < 0.05）。从任务到恢复阶段MAO - AI水平下降的受试者，其HR同时下降的幅度明显大于MAO - AI水平上升的受试者（p < 0.05）。