Lubianca J N, Gordon C M, Laufer M R
Department of Surgery, Children's Hospital, Boston, Massachusetts 02115, USA.
J Reprod Med. 1998 Mar;43(3):164-72.
To review the impact of gonadotropin-releasing hormone agonists (GnRH-as) on bone mass in adolescents and options for GnRH-a with "add-back" for long-term therapy for adolescents with endometriosis not responding to conventional therapy.
Literature research.
The use of GnRH-a plus add-back therapy has not been specifically studied in the adolescent population, and thus the ideal dosage of add-back sex steroids for adolescents has not been delineated.
GnRH-a plus add-back can be considered for usage in adolescents with endometriosis who are refractory to conventional therapy, but steroids are needed to determine the ideal dosage and long-term effects.
