Müller-Höcker J
Pathologisches Institut der Ludwig-Maximilians-Universität München, Germany.
Virchows Arch. 1998 Apr;432(4):349-56. doi: 10.1007/s004280050177.
Oxyphilic hepatocytes, also called hepatic oncocytes, have been found in 20 of 47 cirrhotic livers (42%) with defects of the respiratory chain. Immunohistochemical studies using antisera against cytochrome-c-oxidase (complex IV) revealed respiratory chain-deficient oxyphilic foci in 16 of the 20 cases (75%). Fourteen percent of the oxyphilic areas were deficient, whereas only 8.5% of the nonoxyphilic liver nodules showed respiratory chain defects (P < 0.004). In addition, oxyphilic foci made up about 18% of all defective areas but were present in only 11.5% of the regenerative nodules. These results illustrate that oxyphilic cell change is associated with a higher propensity for the development of respiratory chain defects, but is not obligatory for this.
嗜酸性肝细胞，也称为肝嗜酸性细胞瘤，在47例存在呼吸链缺陷的肝硬化肝脏中有20例（42%）被发现。使用抗细胞色素c氧化酶（复合体IV）抗血清进行的免疫组织化学研究显示，20例中有16例（75%）存在呼吸链缺陷的嗜酸性病灶。14%的嗜酸性区域存在缺陷，而只有8.5%的非嗜酸性肝结节显示呼吸链缺陷（P<0.004）。此外，嗜酸性病灶约占所有缺陷区域的18%，但仅存在于11.5%的再生结节中。这些结果表明，嗜酸性细胞改变与呼吸链缺陷发生的较高倾向相关，但并非必然如此。
