Johnson T F, Reisman R E, Arbesman C E
Clin Allergy. 1975 Dec;5(4):397-401. doi: 10.1111/j.1365-2222.1975.tb01879.x.
Clinical observations and immunological evidence are presented to support a diagnosis of late onset asthma due to exposure to Aspergillus niger in a 70-year-old man. Asthma occurred on only three occasions, each time approximately 6 hr after exposure to an area containing Aspergillus niger. His sputum culture contained the same organism. Immunological correlates using the Aspergillus niger extract included positive immediate and late skin tests, histamine release from leukocytes, and serum precipitins.
现提供临床观察结果和免疫学证据，以支持对一名70岁男性因接触黑曲霉而诊断为迟发性哮喘。哮喘仅发作过三次，每次都是在接触含有黑曲霉的区域后约6小时发作。他的痰培养物中含有相同的生物体。使用黑曲霉提取物进行的免疫学相关检测包括即刻和迟发性皮肤试验阳性、白细胞组胺释放以及血清沉淀素。
