Galant S P, Rucker R W, Groncy C E, Wells I D, Novey H S
Am Rev Respir Dis. 1976 Aug;114(2):325-31. doi: 10.1164/arrd.1976.114.2.325.
The incidence of serum IgE antibodies to several species of aspergillus and the incidence of serum precipitins to these species and to Candida albicans were determined in 22 children with cystic fibrosis, 17 children with bronchial asthma, and 18 control subjects. IgE antibodies were found in 50 per cent of the patients with cystic fibrosis and in 29 per cent of the patients with bronchial asthma; none was found in the control subjects. Precipitins to aspergillus species were present in 59 per cent of the patients with cystic fibrosis, 35 per cent of the patients with bronchial asthma, and 11 per cent of the control subjects. Greater differences were noted when the total number of precipitin bands in each group was compared. There was a trend for the more severe cases of cystic fibrosis (based on the Shwachman-Kulczycki score) to have a greater incidence of precipitins and a lower frequency of IgE antibodies to aspergillus than the milder cases. Candida precipitins were found more frequently in patients with cystic fibrosis (45 per cent) than in patients with bronchial asthma (18 per cent); none was found in the control group. The potential role of fungal hypersensitivity in cystic fibrosis and the therapeutic implications are discussed in light of these findings.
对22例囊性纤维化患儿、17例支气管哮喘患儿和18名对照受试者测定了针对几种曲霉菌的血清IgE抗体发生率以及针对这些曲霉菌和白色念珠菌的血清沉淀素发生率。在50%的囊性纤维化患者和29%的支气管哮喘患者中发现了IgE抗体；对照受试者中未发现。在59%的囊性纤维化患者、35%的支气管哮喘患者和11%的对照受试者中存在针对曲霉菌的沉淀素。比较每组沉淀素带的总数时发现了更大的差异。基于施瓦赫曼 - 库尔奇茨基评分，病情较重的囊性纤维化病例比病情较轻的病例有更高的沉淀素发生率和更低的针对曲霉菌的IgE抗体频率。囊性纤维化患者（45%）中发现念珠菌沉淀素的频率高于支气管哮喘患者（18%）；对照组中未发现。根据这些发现讨论了真菌超敏反应在囊性纤维化中的潜在作用及其治疗意义。
