Kiehl P, Kapp A
Dermatologische Klinik und Poliklinik, Medizinische Hochschule Hannover.
Hautarzt. 1998 Mar;49(3):176-83. doi: 10.1007/s001050050724.
Recent in vitro-studies have substantially increased our knowledge of eosinophil activation, the regulation of eosinophilia in the peripheral blood and the role of cytokines in that process. Accordingly, chemoattraction and activation of eosinophils by cytokines results in the local release of reactive oxygen species and toxic cationic granule proteins followed by local propagation of the inflammatory reaction and tissue damage. This extracellular tissue deposition of toxic granule proteins as an expression of complete activation of eosinophils, rather than only the presence of intact eosinophil granulocytes, is crucial for their functional effect in situ. Semi-quantitative studies of local eosinophil granula deposition so far have been done only in atopic dermatitis and a limited number of other inflammatory skin diseases as summarized in this review. Evaluation of the pathogenetic role of eosinophils may be of potential therapeutic importance.
最近的体外研究极大地增进了我们对嗜酸性粒细胞活化、外周血嗜酸性粒细胞增多的调节以及细胞因子在该过程中作用的了解。相应地，细胞因子对嗜酸性粒细胞的化学趋化和活化导致活性氧物质和有毒阳离子颗粒蛋白的局部释放，随后炎症反应局部扩散并造成组织损伤。这种作为嗜酸性粒细胞完全活化表现的有毒颗粒蛋白在细胞外组织中的沉积，而非仅仅是完整嗜酸性粒细胞的存在，对于其在原位的功能效应至关重要。如本综述所总结，迄今为止，仅在特应性皮炎和其他少数几种炎症性皮肤病中对局部嗜酸性粒细胞颗粒沉积进行了半定量研究。评估嗜酸性粒细胞的致病作用可能具有潜在的治疗意义。
