Leiferman K M
Department of Dermatology, Mayo Clinic, Rochester, MN.
Allergy. 1989;44 Suppl 9:20-6.
The eosinophilic granulocyte is commonly associated with allergic inflammation. Although blood eosinophilia frequently accompanies atopic dermatitis, accumulation of tissue eosinophils is not prominent. Recent studies have elucidated the structure, content, and activities of the eosinophil. In addition, immunofluorescence localization of eosinophil granulate proteins has shown that eosinophils disrupt in tissue depositing toxic granule proteins in several diseases. Here, evidence for eosinophil degranulation in atopic dermatitis is presented and mechanisms whereby eosinophil degranulation may mediate pathophysiologic effects in atopic dermatitis and related conditions are discussed.
嗜酸性粒细胞通常与过敏性炎症相关。尽管血液嗜酸性粒细胞增多常伴随特应性皮炎，但组织嗜酸性粒细胞的聚集并不明显。最近的研究阐明了嗜酸性粒细胞的结构、成分和活性。此外，嗜酸性粒细胞颗粒蛋白的免疫荧光定位表明，在几种疾病中，嗜酸性粒细胞在组织中破裂并沉积有毒颗粒蛋白。本文提供了特应性皮炎中嗜酸性粒细胞脱颗粒的证据，并讨论了嗜酸性粒细胞脱颗粒可能介导特应性皮炎及相关病症病理生理效应的机制。
