Pepine M, Flowers F P, Ramos-Caro F A
Department of Medicine, University of Florida College of Medicine, Gainesville.
J Am Acad Dermatol. 1993 Feb;28(2 Pt 2):292-5. doi: 10.1016/0190-9622(93)70037-t.
A 65-year-old man had cutaneous hyperpigmentation that had occurred over the previous 2 1/2 years. The hyperpigmentation was extensive and involved the sclerae, nail beds, and total body; the palms and buttocks were spared. Clinical diagnosis was suggestive of hemochromatosis or heavy metal deposition. Histologic and electron microscopic findings were consistent with lysosomal iron deposition. A careful history showed that minocycline was the cause. Its use was discontinued, and after several years the patient's pigmentation is gradually returning to normal.
