Buzina-Suboticanec K, Buzina R, Stavljenic A, Farley T M, Haller J, Bergman-Markovic B, Gorajscan M
Institute of Public Health, Zagreb, Croatia.
Int J Vitam Nutr Res. 1998;68(2):133-41.
The effects of vitamin supplementation on the age-related decline in immune function was studied in a population of elderly subjects with a high prevalence of low and deficient serum values of vitamin C, vitamin E, riboflavin and pyridoxin, as well as iron and zinc. The immune function was examined by measuring delayed cutaneous hypersensitivity (DCH) after intradermal application of a set of 7 antigens in 72 subjects aged 60-89 years living in two homes for the elderly. The results showed an almost linear statistically significant decline in the DCH test with age (p < 0.01). Vitamin supplementation for a period of 10 weeks significantly improved the biochemical parameters for those vitamins and the age related decline in the DCH test was no longer statistically significant (P > 0.05). No statistically significant changes in DCH were observed in the placebo group. The results of this study suggest that nutrition may be an important determinant of immunocompetence in the elderly.
在血清维生素C、维生素E、核黄素、吡哆醇以及铁和锌水平低和缺乏发生率较高的老年人群中，研究了补充维生素对与年龄相关的免疫功能下降的影响。在居住在两家养老院的72名60 - 89岁的受试者中，通过皮内注射一组7种抗原后测量迟发型皮肤超敏反应（DCH）来检测免疫功能。结果显示，DCH试验结果随年龄增长几乎呈线性下降，具有统计学意义（p < 0.01）。为期10周的维生素补充显著改善了这些维生素的生化参数，并且DCH试验中与年龄相关的下降不再具有统计学意义（P > 0.05）。在安慰剂组中未观察到DCH有统计学意义的变化。本研究结果表明，营养可能是老年人免疫能力的一个重要决定因素。
