Malec D
Department of Pharmacodynamics, Medical Academy, Lublin, Poland.
Pol J Pharmacol. 1997 Sep-Oct;49(5):323-7.
Cataleptogenic effects of haloperidol (1 mg/kg i.p.) in rats was antagonized by caffeine and theophylline (10-50 mg/kg i.p.), and by selective adenosine A2 receptor antagonist (3,7-dimethyl-1-propargylxanthine) (3 and 6 mg/kg i.p.). Selective A1-adenosine receptor antagonist (8-cyclopentyltheophylline) (1.5 and 3 mg/kg i.p.) was not able to reduce this effect of haloperidol. These results confirm the antagonistic interaction between adenosine A2A and dopamine D2 receptors, and suggest the involvement of adenosine A2 receptors in the mechanisms of catalepsy.
氟哌啶醇（腹腔注射1毫克/千克）对大鼠产生的僵住效应被咖啡因和茶碱（腹腔注射10 - 50毫克/千克）以及选择性腺苷A2受体拮抗剂（3,7 - 二甲基 - 1 - 丙炔基黄嘌呤）（腹腔注射3和6毫克/千克）所拮抗。选择性A1 - 腺苷受体拮抗剂（8 - 环戊基茶碱）（腹腔注射1.5和3毫克/千克）未能降低氟哌啶醇的这种效应。这些结果证实了腺苷A2A和多巴胺D2受体之间的拮抗相互作用，并提示腺苷A2受体参与了僵住症的机制。
