Weinehall L, Johnson O, Jansson J H, Boman K, Huhtasaari F, Hallmans G, Dahlen G H, Wall S
Department of Epidemiology and Public Health, Umeå University, Sweden.
J Intern Med. 1998 Feb;243(2):99-107. doi: 10.1046/j.1365-2796.1998.00201.x.
To assess the importance of biomedical risk factors, social factors and self-reported health in the prediction of the first event of acute myocardial infarction (AMI) in an apparently healthy middle-aged population.
An incident case-control study.
The study was nested within the Västerbotten Intervention Program and the Northern Sweden MONICA cohorts.
The study consists of 78 AMI cases with two randomly selected controls per case from the same study cohorts.
Significant odds ratios were found for history of diabetes, daily smoking, cholesterol, body-mass index, hypertension, lower education and perceived ill health. In multivariate logistic regression smoking, hypertension and cholesterol of > or =7.8 mmol L(-1) remained significant. An interaction was observed between number of biomedical risk factors and perceived health.
Smoking, hypertension and hypercholesterolaemia explain a major share of incident AMI events in a Swedish middle-aged population. The study further illustrates that perceived ill health negatively modifies the impact of these risk factors.
评估生物医学风险因素、社会因素及自我报告的健康状况对表面健康的中年人群首次急性心肌梗死（AMI）事件预测的重要性。
一项病例对照研究。
该研究嵌套于韦斯特博滕干预项目和瑞典北部莫尼卡队列研究中。
该研究包括78例AMI病例，每例病例从同一研究队列中随机选取两名对照。
发现糖尿病史、每日吸烟、胆固醇、体重指数、高血压、低教育水平和自我感觉健康状况不佳的比值比有显著意义。在多因素逻辑回归分析中，吸烟、高血压和胆固醇水平≥7.8 mmol/L仍具有显著意义。观察到生物医学风险因素数量与自我感觉健康状况之间存在交互作用。
吸烟、高血压和高胆固醇血症在瑞典中年人群AMI事件中占很大比例。该研究进一步表明，自我感觉健康状况不佳会对这些风险因素的影响产生负面作用。
