• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Axil, a member of the Axin family, interacts with both glycogen synthase kinase 3beta and beta-catenin and inhibits axis formation of Xenopus embryos.Axil是Axin家族的成员之一，它与糖原合酶激酶3β和β-连环蛋白相互作用，并抑制非洲爪蟾胚胎的轴形成。
Mol Cell Biol. 1998 May;18(5):2867-75. doi: 10.1128/MCB.18.5.2867.
2
Regulation of glycogen synthase kinase 3beta and downstream Wnt signaling by axin.轴蛋白对糖原合酶激酶3β及下游Wnt信号通路的调控
Mol Cell Biol. 1999 Oct;19(10):7147-57. doi: 10.1128/MCB.19.10.7147.
3
Modulation of Wnt signaling by Axin and Axil.Axin和Axil对Wnt信号通路的调控
Cytokine Growth Factor Rev. 1999 Sep-Dec;10(3-4):255-65. doi: 10.1016/s1359-6101(99)00017-9.
4
Inhibition of Wnt signaling pathway by a novel axin-binding protein.一种新型轴蛋白结合蛋白对Wnt信号通路的抑制作用。
J Biol Chem. 2000 Nov 24;275(47):37030-7. doi: 10.1074/jbc.M005984200.
5
Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin.Axin是Wnt信号通路的负调节因子，它与糖原合成酶激酶3β（GSK-3β）和β-连环蛋白形成复合物，并促进GSK-3β依赖的β-连环蛋白磷酸化。
EMBO J. 1998 Mar 2;17(5):1371-84. doi: 10.1093/emboj/17.5.1371.
6
Interaction among GSK-3, GBP, axin, and APC in Xenopus axis specification.非洲爪蟾体轴形成过程中糖原合成酶激酶-3（GSK-3）、鸟苷酸结合蛋白（GBP）、轴抑制蛋白（axin）和腺瘤性息肉病蛋白（APC）之间的相互作用。
J Cell Biol. 2000 Feb 21;148(4):691-702. doi: 10.1083/jcb.148.4.691.
7
Relationship of vegetal cortical dorsal factors in the Xenopus egg with the Wnt/beta-catenin signaling pathway.非洲爪蟾卵中植物性皮质背侧因子与Wnt/β-连环蛋白信号通路的关系。
Mech Dev. 1999 Dec;89(1-2):93-102. doi: 10.1016/s0925-4773(99)00210-5.
8
Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization.Axin参与蛋白质-蛋白质相互作用、Wnt信号通路抑制及细胞内定位的结构域。
J Cell Biol. 1999 May 17;145(4):741-56. doi: 10.1083/jcb.145.4.741.
9
Axin, an inhibitor of the Wnt signalling pathway, interacts with beta-catenin, GSK-3beta and APC and reduces the beta-catenin level.轴抑制蛋白（Axin）是一种Wnt信号通路抑制剂，可与β-连环蛋白、糖原合成酶激酶3β（GSK-3β）和腺瘤性息肉病蛋白（APC）相互作用，并降低β-连环蛋白水平。
Genes Cells. 1998 Jun;3(6):395-403. doi: 10.1046/j.1365-2443.1998.00198.x.
10
Axis determination in Xenopus involves biochemical interactions of axin, glycogen synthase kinase 3 and beta-catenin.非洲爪蟾的体轴决定涉及轴蛋白、糖原合酶激酶3和β-连环蛋白的生化相互作用。
Curr Biol. 1998 May 7;8(10):591-4. doi: 10.1016/s0960-9822(98)70229-5.

引用本文的文献

1
Semaphorin Receptors Antagonize Wnt Signaling Through Beta-Catenin Degradation.信号素受体通过β-连环蛋白降解拮抗Wnt信号通路。
bioRxiv. 2024 May 29:2024.05.29.596372. doi: 10.1101/2024.05.29.596372.
2
Nkd1 functions downstream of Axin2 to attenuate Wnt signaling.Nkd1 在 Axin2 下游发挥作用，从而减弱 Wnt 信号。
Mol Biol Cell. 2024 Jul 1;35(7):ar93. doi: 10.1091/mbc.E24-02-0059-T. Epub 2024 Apr 24.
3
R-spondin-1 induces Axin degradation via the LRP6-CK1ε axis.R-spondin-1 通过 LRP6-CK1ε 轴诱导 Axin 降解。
Cell Commun Signal. 2024 Jan 5;22(1):14. doi: 10.1186/s12964-023-01456-y.
4
Genetic Factors of Teeth Impaction: Polymorphic and Haplotype Variants of , , , and Genes.牙齿阻生的遗传因素：、、和基因的多态性及单倍型变异
Int J Mol Sci. 2023 Sep 9;24(18):13889. doi: 10.3390/ijms241813889.
5
TWIST1 induces proteasomal degradation of β-catenin during the differentiation of ovarian cancer stem-like cells.TWIST1 在卵巢癌细胞干细胞样分化过程中诱导β-catenin 的蛋白酶体降解。
Sci Rep. 2022 Sep 19;12(1):15650. doi: 10.1038/s41598-022-18662-2.
6
Cancer Genomic Profiling in Colorectal Cancer: Current Challenges in Subtyping Colorectal Cancers Based on Somatic and Germline Variants.结直肠癌的癌症基因组分析：基于体细胞和种系变异对结直肠癌进行亚型分类的当前挑战
J Anus Rectum Colon. 2021 Jul 29;5(3):213-228. doi: 10.23922/jarc.2021-009. eCollection 2021.
7
Coordinated changes in the expression of Wnt pathway genes following human and rat peripheral nerve injury.人及大鼠周围神经损伤后 Wnt 通路基因表达的协同变化。
PLoS One. 2021 Apr 13;16(4):e0249748. doi: 10.1371/journal.pone.0249748. eCollection 2021.
8
Axin Family of Scaffolding Proteins in Development: Lessons from .发育过程中支架蛋白的Axin家族：来自……的经验教训
J Dev Biol. 2019 Oct 15;7(4):20. doi: 10.3390/jdb7040020.
9
Functions of the APC tumor suppressor protein dependent and independent of canonical WNT signaling: implications for therapeutic targeting.APC 肿瘤抑制蛋白的功能依赖和不依赖于经典 WNT 信号通路：对治疗靶点的影响。
Cancer Metastasis Rev. 2018 Mar;37(1):159-172. doi: 10.1007/s10555-017-9725-6.
10
Cellular heterogeneity in the ureteric progenitor niche and distinct profiles of branching morphogenesis in organ development.输尿管祖细胞龛中的细胞异质性与器官发育中分支形态发生的不同特征。
Development. 2017 Sep 1;144(17):3177-3188. doi: 10.1242/dev.149112. Epub 2017 Jul 13.

本文引用的文献

1
The effects of a lethal mutation responsible for duplications and twinning in mouse embryos.一种导致小鼠胚胎出现重复和孪生现象的致死突变的影响。
J Exp Zool. 1949 Feb;110(1):47-76. doi: 10.1002/jez.1401100105.
2
The Inheritance and Expression of Fused, a New Mutation in the House Mouse.小家鼠新突变体Fused的遗传与表达
Genetics. 1937 Jan;22(1):1-13. doi: 10.1093/genetics/22.1.1.
3
Axin, a negative regulator of the wnt signaling pathway, directly interacts with adenomatous polyposis coli and regulates the stabilization of beta-catenin.Axin是Wnt信号通路的负调节因子，它直接与腺瘤性息肉病蛋白相互作用并调节β-连环蛋白的稳定性。
J Biol Chem. 1998 May 1;273(18):10823-6. doi: 10.1074/jbc.273.18.10823.
4
Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin.Axin是Wnt信号通路的负调节因子，它与糖原合成酶激酶3β（GSK-3β）和β-连环蛋白形成复合物，并促进GSK-3β依赖的β-连环蛋白磷酸化。
EMBO J. 1998 Mar 2;17(5):1371-84. doi: 10.1093/emboj/17.5.1371.
5
Identification and characterization of a novel protein interacting with Ral-binding protein 1, a putative effector protein of Ral.一种与Ral结合蛋白1相互作用的新型蛋白质的鉴定与表征，Ral结合蛋白1是Ral的一种假定效应蛋白。
J Biol Chem. 1998 Jan 9;273(2):814-21. doi: 10.1074/jbc.273.2.814.
6
Interaction of Wnt and a Frizzled homologue triggers G-protein-linked phosphatidylinositol signalling.Wnt与卷曲同源物的相互作用触发G蛋白偶联的磷脂酰肌醇信号传导。
Nature. 1997 Nov 27;390(6658):410-3. doi: 10.1038/37138.
7
beta-catenin is a target for the ubiquitin-proteasome pathway.β-连环蛋白是泛素-蛋白酶体途径的作用靶点。
EMBO J. 1997 Jul 1;16(13):3797-804. doi: 10.1093/emboj/16.13.3797.
8
The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation.小鼠融合基因座编码Axin，它是一种调节胚胎轴形成的Wnt信号通路抑制剂。
Cell. 1997 Jul 11;90(1):181-92. doi: 10.1016/s0092-8674(00)80324-4.
9
The adenomatous polyposis coli (APC) tumor suppressor.腺瘤性结肠息肉病蛋白（APC）肿瘤抑制因子
Biochim Biophys Acta. 1997 Jun 7;1332(3):F127-47. doi: 10.1016/s0304-419x(97)00008-5.
10
A versatile transcriptional effector of Wingless signaling.一种多功能的无翅信号转录效应因子。
Cell. 1997 May 2;89(3):321-3. doi: 10.1016/s0092-8674(00)80210-x.

Axil是Axin家族的成员之一，它与糖原合酶激酶3β和β-连环蛋白相互作用，并抑制非洲爪蟾胚胎的轴形成。

Axil, a member of the Axin family, interacts with both glycogen synthase kinase 3beta and beta-catenin and inhibits axis formation of Xenopus embryos.

作者信息

Yamamoto H, Kishida S, Uochi T, Ikeda S, Koyama S, Asashima M, Kikuchi A

机构信息

Department of Biochemistry, Hiroshima University School of Medicine, Japan.

出版信息

Mol Cell Biol. 1998 May;18(5):2867-75. doi: 10.1128/MCB.18.5.2867.

DOI:10.1128/MCB.18.5.2867
PMID:9566905
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC110665/
Abstract

Using a yeast two-hybrid method, we identified a novel protein which interacts with glycogen synthase kinase 3beta (GSK-3beta). This protein had 44% amino acid identity with Axin, a negative regulator of the Wnt signaling pathway. We designated this protein Axil for Axin like. Like Axin, Axil ventralized Xenopus embryos and inhibited Xwnt8-induced Xenopus axis duplication. Axil was phosphorylated by GSK-3beta. Axil bound not only to GSK-3beta but also to beta-catenin, and the GSK-3beta-binding site of Axil was distinct from the beta-catenin-binding site. Furthermore, Axil enhanced GSK-3beta-dependent phosphorylation of beta-catenin. These results indicate that Axil negatively regulates the Wnt signaling pathway by mediating GSK-3beta-dependent phosphorylation of beta-catenin, thereby inhibiting axis formation.

摘要

我们使用酵母双杂交方法鉴定出一种与糖原合酶激酶3β（GSK-3β）相互作用的新型蛋白质。该蛋白质与Wnt信号通路的负调节因子Axin具有44%的氨基酸同一性。我们将这种蛋白质命名为Axil，表示其与Axin相似。与Axin一样，Axil使非洲爪蟾胚胎腹化，并抑制Xwnt8诱导的非洲爪蟾轴重复。Axil被GSK-3β磷酸化。Axil不仅与GSK-3β结合，还与β-连环蛋白结合，且Axil的GSK-3β结合位点与β-连环蛋白结合位点不同。此外，Axil增强了GSK-3β依赖的β-连环蛋白磷酸化。这些结果表明，Axil通过介导GSK-3β依赖的β-连环蛋白磷酸化来负调节Wnt信号通路，从而抑制轴形成。