Odano I, Ohkubo M, Noguchi E, Ohtaki H, Shibaki M, Dobashi S
Department of Radiology, Niigata University School of Medicine.
Kaku Igaku. 1998 Feb;35(2):71-5.
The purpose of the study is to develop a simple and less invasive method for quantifying regional cerebral blood flow (rCBF) at pre- and post Diamox test using split-dose 99mTc-ECD and SPECT. By employing a microsphere model, integral of input function was calculated by the one-point venous sampling method previously reported. The study was performed on 5 subjects with cerebrovascular diseases. A split dose of 99mTc-ECD was injected pre- and post Diamox injection, and rCBF was measured by two SPECT scans and single venous samples, respectively. Mean CBF obtained by the present method was 0.47 +/- 0.07 ml/g/min at the control state, and 0.63 +/- 0.12 ml/g/min loaded with Diamox (mean % increase; 35%), showing good agreement with those obtained by the 133Xe-inhalation method. Since the present method does not require arterial blood sampling, dynamic data acquisition and dose corrections, it is simple, less invasive and useful in clinical SPECT studies.
本研究的目的是开发一种简单且侵入性较小的方法，用于在使用分剂量99mTc-ECD和SPECT进行乙酰唑胺试验前后定量测定局部脑血流量（rCBF）。通过采用微球模型，利用先前报道的单点静脉采样法计算输入函数的积分。该研究在5名脑血管疾病患者身上进行。在注射乙酰唑胺前后分别注射分剂量的99mTc-ECD，并分别通过两次SPECT扫描和单次静脉采样测量rCBF。本方法在对照状态下获得的平均脑血流量为0.47±0.07 ml/g/min，注射乙酰唑胺后为0.63±0.12 ml/g/min（平均增加百分比；35%），与通过133Xe吸入法获得的结果显示出良好的一致性。由于本方法不需要动脉血采样、动态数据采集和剂量校正，因此简单、侵入性小，在临床SPECT研究中很有用。
