Tomioka H, Fujiyama R, Ohnishi H, Sakurai T, Tada K, Sakamoto H, Iwasaki H, Imanaka K, Hashimoto K
Department of Respiratory Medicine, Nishi-Kobe Medical Center, Japan.
Nihon Kyobu Shikkan Gakkai Zasshi. 1997 Dec;35(12):1389-94.
Langerhans cell granulomatosis, once called histiocytosis X, is a rare disease. A case of multifocal Langerhans cell granulomatosis in the bone, lymph nodes, skin and lungs of an 18-year-old man is described. Head CT and MRI showed a soft tissue mass of the left temporal bone. Lymph node and skin biopsies substantiated a diagnosis of Langerhans cell granulomatosis. A High resolution CT scan of the lung revealed a small cystic lesion, and bronchoalveolar lavage (BAL) showed an increased number of S-100 positive cells. Steroid therapy resulted in complete resolution, and no S-100 positive cells were obtained in the follow-up BAL study.
