Rajendram R, Rose G, Luthert P, Plowman P, Pearson A
Berkshire Eye Service, King Edward VII Hospital, Windsor.
Orbit. 2005 Mar;24(1):39-41. doi: 10.1080/01676830590889893.
A 17-year-old boy presented with a left upper lid swelling, headaches and diplopia. An orbital computerized tomography (CT) scan showed a mass in the left lacrimal fossa eroding bone and extending into the temporalis fossa and intracranially. An urgent biopsy without curettage was carried out and showed Langerhans cell histiocytosis. He was otherwise well and no other lesion was found. He was therefore observed and reviewed regularly. During follow-up it was noted that the mass was reducing in size. Five months after the initial biopsy a further procedure, involving curettage and an intralesional steroid, was carried out at a tertiary referral center. Histology of the material obtained showed no remaining evidence of Langerhans cell histiocytosis. Spontaneous resolution of orbital Langerhans cell histiocytosis has been described clinically and radiologically. This is the first case of spontaneous resolution to be confirmed histologically.
一名17岁男孩出现左上睑肿胀、头痛和复视。眼眶计算机断层扫描（CT）显示左泪窝有一肿块，侵蚀骨质并延伸至颞窝和颅内。进行了紧急活检（未刮除），结果显示为朗格汉斯细胞组织细胞增多症。他其他方面情况良好，未发现其他病变。因此对其进行观察并定期复查。随访期间注意到肿块尺寸在减小。初次活检五个月后，在一家三级转诊中心进行了进一步的手术，包括刮除和病灶内注射类固醇。所获材料的组织学检查未发现朗格汉斯细胞组织细胞增多症的残留证据。眼眶朗格汉斯细胞组织细胞增多症的自发消退在临床和放射学上均有描述。这是首例经组织学证实的自发消退病例。
