Chanh T C, Benedict A A, Abplanalp H
J Exp Med. 1976 Aug 1;144(2):555-61. doi: 10.1084/jem.144.2.555.
The total hemolytic complement (C) levels in inbred line 7 chicks and adults were lower than C levels in inbred lines 2 and 3 and in outbred chickens of the same age. In all birds, adult levels of C were obtained in 5- to 6-wk-old chickens. Analysis of F1 and F3 generations clearly showed that the C level in chickens was determined by a dominant gene(s) associated with the major histocompatibility complex. Finding this association in a nonmammal strengthens the importance of the relationship between closely linked genes controlling histocompatibility, immune responsiveness, mixed leukocyte reaction, and C activity.
近交系7雏鸡和成年鸡的总溶血补体（C）水平低于近交系2和3以及同龄远交鸡的C水平。在所有鸡中，5至6周龄的鸡达到了成年C水平。对F1和F3代的分析清楚地表明，鸡的C水平由与主要组织相容性复合体相关的一个显性基因决定。在非哺乳动物中发现这种关联强化了控制组织相容性、免疫反应性、混合淋巴细胞反应和C活性的紧密连锁基因之间关系的重要性。
