Amato Neto V, Pasternak J, de Souza E R, Costa A M, Matsubara L
Laboratório de Investigação Médica-Parasitologia do Hospital das Clínicas, da Faculdade de Medicina da Universidade de São Paulo.
Rev Hosp Clin Fac Med Sao Paulo. 1997 Jul-Aug;52(4):195-6.
Cyclosporin A has activity "in vitro" against trypomastigotes of Trypanosoma cruzi. We tried to evaluate, in an "in vitro" model, using variable concentrations in whole blood contaminated with known numbers of parasites and injecting this blood after a two hour incubation period in mice if it was possible to prevent infection. In this model the drug, in the concentrations used, was unable to prevent infection.
