Effect of ibuprofen and diclofenac sodium on experimental would healing.

Effects of frequently used anti-inflammatory drugs ibuprofen and diclofenac was studied on experimental wound healing in rats. These drugs impede tissue repair by virtue of retarding inflammation. There was 16-36% reduction in wound strength measured in terms of tensile strength in experimental rats. The detrimental effect of anti-inflammatory drugs was confirmed by histological examination of wound and by measuring dry granuloma weight.