布洛芬和双氯芬酸钠对实验性伤口愈合的影响。
Effect of ibuprofen and diclofenac sodium on experimental would healing.
作者信息
Dvivedi S, Tiwari S M, Sharma A
机构信息
Department of General Surgery, G R Medical College, Gwalior, India.
出版信息
Indian J Exp Biol. 1997 Nov;35(11):1243-5.
PMID:9567757
Abstract
Effects of frequently used anti-inflammatory drugs ibuprofen and diclofenac was studied on experimental wound healing in rats. These drugs impede tissue repair by virtue of retarding inflammation. There was 16-36% reduction in wound strength measured in terms of tensile strength in experimental rats. The detrimental effect of anti-inflammatory drugs was confirmed by histological examination of wound and by measuring dry granuloma weight.
摘要
研究了常用抗炎药布洛芬和双氯芬酸对大鼠实验性伤口愈合的影响。这些药物通过抑制炎症来阻碍组织修复。在实验大鼠中，以抗张强度衡量的伤口强度降低了16%至36%。通过伤口的组织学检查和测量干肉芽肿重量证实了抗炎药的有害作用。
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