Center for Wound Healing and Tissue Regeneration, Department of Periodontics, College of Dentistry (MC 859), University of Illinois at Chicago, 801 S. Paulina Ave., Chicago, IL 60612, USA.
J Dent Res. 2010 Mar;89(3):219-29. doi: 10.1177/0022034509359125. Epub 2010 Feb 5.
Wound healing, as a normal biological process in the human body, is achieved through four precisely and highly programmed phases: hemostasis, inflammation, proliferation, and remodeling. For a wound to heal successfully, all four phases must occur in the proper sequence and time frame. Many factors can interfere with one or more phases of this process, thus causing improper or impaired wound healing. This article reviews the recent literature on the most significant factors that affect cutaneous wound healing and the potential cellular and/or molecular mechanisms involved. The factors discussed include oxygenation, infection, age and sex hormones, stress, diabetes, obesity, medications, alcoholism, smoking, and nutrition. A better understanding of the influence of these factors on repair may lead to therapeutics that improve wound healing and resolve impaired wounds.
伤口愈合是人体正常的生物学过程，通过四个精确且高度程序化的阶段来实现：止血、炎症、增殖和重塑。为了使伤口成功愈合，所有四个阶段都必须按照正确的顺序和时间框架发生。许多因素会干扰这个过程的一个或多个阶段，从而导致伤口愈合不当或受损。本文综述了最近关于影响皮肤伤口愈合的最重要因素的文献，以及涉及的潜在细胞和/或分子机制。讨论的因素包括氧合作用、感染、年龄和性激素、压力、糖尿病、肥胖、药物、酗酒、吸烟和营养。更好地了解这些因素对修复的影响可能会导致改善伤口愈合和解决受损伤口的治疗方法。
