毛叶杨桃的肝脏保护作用

Hepatoprotection with Glycosmis pentaphylla (Retz).

作者信息

Mitra S, Sur R K

机构信息

Department of Zoology, College of Science and Technology, Calcutta, India.

出版信息

Indian J Exp Biol. 1997 Dec;35(12):1306-9.

PMID:9567765

Abstract

Effects of extracts of leaf (250, 500 and 750 mg/kg body wt) and stem bark (100, 200 and 400 mg/kg body wt) of G. pentaphylla were studied on CCl4 (1 mg/kg body wt) induced hepatic injury in albino rats. Parameters studied were plasma ALAT, ASAT, ALP, total bilirubin and tissue histopathology. Recovery of hepatic tissue was indicated with the highest dose (750 mg/kg body wt) of leaf extract. The therapeutic dose range was devoid of toxic effects. Toxicity of leaf extract was observed histopathologically at and above 2.5g/kg body wt.

摘要

研究了五指柑叶提取物（250、500和750毫克/千克体重）和茎皮提取物（100、200和400毫克/千克体重）对四氯化碳（1毫克/千克体重）诱导的白化大鼠肝损伤的影响。所研究的参数包括血浆谷丙转氨酶、谷草转氨酶、碱性磷酸酶、总胆红素和组织病理学。叶提取物的最高剂量（750毫克/千克体重）表明肝组织有恢复。治疗剂量范围没有毒性作用。在2.5克/千克体重及以上时，通过组织病理学观察到叶提取物有毒性。