Ensinger C, Obrist P, Bacher-Stier C, Mikuz G, Moncayo R, Riccabona G
Institute of Pathology, University of Innsbruck, Austria.
Anticancer Res. 1998 Jan-Feb;18(1A):33-40.
beta 1-integrins are widespread adhesion molecules which belong to a family of heterodimeric membrane glycoproteins and consist of two subunits, alpha and beta. Integrins seem to play an important role in the spreading and metastasis of malignant tumors. We investigated the expression and distribution of these adhesion molecules on papillary thyroid carcinomas by immunohistochemistry on formalin-fixed, paraffin embedded cancer tissues. We estimated the beta 1-integrin expression in cancerous areas in comparison to normal adjacent thyroid tissue. Our results revealed a highly significant difference in all investigated parameters between cancer and normal thyroid cells (p < 0.0001). Comparing our findings with the metastatic potential of the primary thyroid tumors, our results show that beta 1-integrin expression could be used as a prognostic parameter for papillary thyroid tumors.
β1整合素是广泛存在的黏附分子，属于异二聚体膜糖蛋白家族，由α和β两个亚基组成。整合素似乎在恶性肿瘤的扩散和转移中起重要作用。我们通过对福尔马林固定、石蜡包埋的癌组织进行免疫组织化学研究，调查了这些黏附分子在甲状腺乳头状癌中的表达和分布。我们评估了癌组织区域与相邻正常甲状腺组织中β1整合素的表达情况。我们的结果显示，癌组织与正常甲状腺细胞在所有研究参数上存在高度显著差异（p < 0.0001）。将我们的研究结果与原发性甲状腺肿瘤的转移潜能进行比较，结果表明β1整合素表达可用作甲状腺乳头状肿瘤的预后参数。
