Ludin H P, Bass-Verrey F
J Neural Transm. 1976;38(3-4):249-58. doi: 10.1007/BF01249442.
35 parkinsonian patients have been treated over 3 years with L-Dopa combined with benserazide. After an impressive improvement during the first months of treatment a slow but significant deterioration of the patient's condition was observed. At the end of the observation period however their condition was still significantly better than before starting the treatment. A reduced mean L-Dopa dosage was ruled out as the cause of this deterioration. Withdrawal of the L-Dopa therapy for a few days in 13 patients provided strong evidence that it is due to the progression of the disease and to a partial loss of L-Dopa efficacy.
35名帕金森病患者接受了为期3年的左旋多巴联合苄丝肼治疗。在治疗的最初几个月里病情有显著改善之后，观察到患者病情出现缓慢但明显的恶化。然而，在观察期结束时，他们的病情仍明显好于开始治疗前。排除了平均左旋多巴剂量减少是导致这种恶化的原因。13名患者停用左旋多巴治疗数天，有力地证明这是由于疾病进展以及左旋多巴疗效部分丧失所致。
