Myśliwski A, Szmit E, Szatkowski D, Sosnowska D
Department of Histology and Immunology, Medical University of Gdańsk, Poland.
Anticancer Res. 1998 Jan-Feb;18(1A):441-3.
The growth of solid tumors and their metastasis is dependent on the development of new blood vessels (angiogenesis). In this study, we examined the effect of the angiogenesis inhibitor TNP-470 on a fast growing melanoma in hamsters. The effect was observed both on tumor growth and metastasis. Treatment with TNP-470 caused a significant decrease in the rate of tumor growth and suppression of the development of metastasis in 63% of treated animals. Some of the hamsters treated with TNP-470 had the tumor excised and the effect of that operation on the development of metastasis was examined. In such cases the inhibitory effect of TNP-470 was weaker than in tumor bearing animals. This indicates that excision of tumor created more favourable conditions for angiogenesis and that the dose of TNP-470 should be increased to be effective in such conditions.
实体瘤的生长及其转移依赖于新血管的形成（血管生成）。在本研究中，我们检测了血管生成抑制剂TNP - 470对仓鼠快速生长的黑色素瘤的作用。该作用在肿瘤生长和转移方面均有观察到。用TNP - 470治疗导致肿瘤生长速率显著降低，并且在63%的受试动物中抑制了转移的发生。一些用TNP - 470治疗的仓鼠切除了肿瘤，并检测了该手术对转移发生的影响。在这些情况下，TNP - 470的抑制作用比荷瘤动物中的作用弱。这表明切除肿瘤为血管生成创造了更有利的条件，并且在这种情况下应增加TNP - 470的剂量以使其有效。
