Myśliwski Andrzej, Kubasik-Juraniec Jolanta, Koszałka Patrycja, Szmit Ewa
Department of Histology and Immunology, Medical University, Gdańsk, Poland.
Folia Morphol (Warsz). 2004 Feb;63(1):5-9.
The growth of solid tumours and their metastases is dependent on the development of new blood vessels (angiogenesis). Therefore angiogenesis inhibitors are potential antitumour drugs. In our previous studies it was found that the angiogenesis inhibitor TNP-470 given to transplantable melanoma-bearing hamsters can decrease the rate of the tumour growth, although the survival time of the animals treated was not significantly affected. It was found finally that TNP-470 given in the vicinity of the growing tumour can cause complete remission of the melanoma in hamsters treated in this way. To check what side-effects could be evoked by such treatment, an examination of the morphology of the blood vessels of the lungs, kidneys and livers of the treated animals was carried out. It was found that the angiogenesis inhibitor applied did not cause any changes which could be observed by light and electron microscopes in the structure of the examined blood vessels of the treated animals.
实体瘤及其转移灶的生长依赖于新血管的形成（血管生成）。因此，血管生成抑制剂是潜在的抗肿瘤药物。在我们之前的研究中发现，给携带可移植黑色素瘤的仓鼠使用血管生成抑制剂TNP - 470，可降低肿瘤生长速度，尽管接受治疗的动物存活时间未受到显著影响。最终发现，在生长中的肿瘤附近给予TNP - 470可使以这种方式治疗的仓鼠黑色素瘤完全缓解。为了检查这种治疗可能引发哪些副作用，对接受治疗动物的肺、肾和肝脏血管形态进行了检查。结果发现，所应用的血管生成抑制剂未在接受治疗动物的被检查血管结构中引起任何光学显微镜和电子显微镜下可观察到的变化。
