Raedler T J, Knable M B, Weinberger D R
National Institute of Mental Health, Clinical Brain Disorders Branch, Washington, DC 20032, USA.
Curr Opin Neurobiol. 1998 Feb;8(1):157-61. doi: 10.1016/s0959-4388(98)80019-6.
The hypothesis that schizophrenia results from a developmental, as opposed to a degenerative, process affecting the cerebral cortex has become popular in current thinking about the disorder. While many of the data gathered in support of this hypothesis do not in themselves represent conclusive proof, an intriguing picture is emerging from a variety of research approaches. These approaches include the observation of minor physical anomalies, premorbid neuropsychological and social deficits, obstetrical complications, and exposure to adverse intrauterine events. Morphometric brain measurement techniques and neuropathological studies have perhaps provided more substantial support.
精神分裂症源于影响大脑皮层的发育过程而非退化过程这一假说，在当前对该疾病的认识中已变得流行起来。虽然为支持这一假说而收集的许多数据本身并不代表确凿的证据，但从各种研究方法中正在浮现出一幅引人入胜的图景。这些方法包括对轻微身体异常、病前神经心理和社会缺陷、产科并发症以及子宫内不良事件暴露情况的观察。脑形态测量技术和神经病理学研究或许提供了更有力的支持。
