Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Department of Neuroscience and Mahoney Institute for Neurosciences, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Institute for Regenerative Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Biol Psychiatry. 2023 Apr 1;93(7):594-605. doi: 10.1016/j.biopsych.2022.12.015. Epub 2022 Dec 24.
Human society has been burdened by psychiatric disorders throughout the course of its history. The emergence and rapid advances of human brain organoid technology provide unprecedented opportunities for investigation of potential disease mechanisms and development of targeted or even personalized treatments for various psychiatric disorders. In this review, we summarize recent advances for generating organoids from human pluripotent stem cells to model distinct brain regions and diverse cell types. We also highlight recent progress, discuss limitations, and propose potential improvements in using patient-derived or genetically engineered brain region-specific organoids for investigating various psychiatric disorders.
人类社会在其历史进程中一直受到精神疾病的困扰。人类大脑类器官技术的出现和快速发展为探索潜在疾病机制以及为各种精神疾病开发靶向甚至个体化治疗方法提供了前所未有的机会。在这篇综述中，我们总结了最近从人类多能干细胞生成类器官以模拟不同脑区和多种细胞类型的进展。我们还强调了最近的进展，讨论了局限性，并提出了使用患者来源或基因工程脑区特异性类器官来研究各种精神疾病的潜在改进方法。
