Yamashiki M, Nishimura A, Nobori T, Nakabayashi S, Takagi T, Inoue K, Ito M, Matsushita K, Ohtaki H, Kosaka Y
Department of Laboratory Medicine, Mie University School of Medicine, Tsu, Japan.
Int J Immunopharmacol. 1997 Jul;19(7):381-5. doi: 10.1016/s0192-0561(97)00064-7.
During the past 2 years, drug-induced interstitial pneumonia was reported in 66 Japanese patients, mainly among chronic hepatitis C patients, undergoing treatment with the Japanese herbal medicine "Sho-saiko-to" (TJ-9). As interstitial pneumonia is also induced by granulocyte colony-stimulating factor (G-CSF), we examined the effects of TJ-9 on G-CSF production in peripheral blood mononuclear cells. In patients with hepatitis B or C, G-CSF production in the absence of any stimulation was significantly lower than healthy controls (p < 0.01). G-CSF production increased along with the increase of TJ-9 levels, and this could induce excessive production of G-CSF in hepatitis C patients, and this may be a cause of interstitial pneumonia.
在过去两年中，66名日本患者报告了药物性间质性肺炎，主要是在接受日本草药“小柴胡汤”（TJ-9）治疗的慢性丙型肝炎患者中。由于粒细胞集落刺激因子（G-CSF）也可诱发间质性肺炎，我们研究了TJ-9对外周血单核细胞中G-CSF产生的影响。在乙型或丙型肝炎患者中，在没有任何刺激的情况下G-CSF的产生明显低于健康对照组（p <0.01）。G-CSF的产生随着TJ-9水平的升高而增加，这可能导致丙型肝炎患者G-CSF的过度产生，这可能是间质性肺炎的一个原因。
