Foelber R
Georgetown University Medical Center, Washington, DC, USA.
Oncol Nurs Forum. 1998 Apr;25(3):563-8.
PURPOSE/OBJECTIVES: To review the role of transplantation in breast cancer and describe the experience of one bone marrow transplant (BMT) program using autologous peripheral blood stem cell transplant (PBSCT) and interleukin-2 (IL-2) for the treatment of breast cancer.
Published articles, chart review, personal experience.
Toxicities experienced by patients on this autologous PBSCT protocol that can be ascribed to low-dose IL-2 included nausea and vomiting, diarrhea, and skin rash.
The most frequently occurring toxicities associated with low-dose IL-2 are not life-threatening. They do, however, affect the patient's quality of life and are toxicities that should be amenable to nursing interventions.
Oncology nurses must be aware of the side effects of different combination therapies (e.g., BMT, biotherapy). Nursing research is needed concerning the management of these toxicities when they occur because of combination therapies.
目的/目标：回顾移植在乳腺癌治疗中的作用，并描述一个使用自体外周血干细胞移植（PBSCT）和白细胞介素-2（IL-2）治疗乳腺癌的骨髓移植（BMT）项目的经验。
发表的文章、病历回顾、个人经验。
接受这种自体PBSCT方案治疗的患者所经历的、可归因于低剂量IL-2的毒性反应包括恶心、呕吐、腹泻和皮疹。
与低剂量IL-2相关的最常见毒性反应并非危及生命。然而，它们确实会影响患者的生活质量，并且是适合护理干预的毒性反应。
肿瘤护士必须了解不同联合治疗（如BMT、生物治疗）的副作用。当因联合治疗出现这些毒性反应时，需要进行关于其管理的护理研究。
