Glover D, Labadie E L
J Neurosurg. 1976 Oct;45(4):393-7. doi: 10.3171/jns.1976.45.4.0393.
A previously described experimental hematoma model, achieved by the subcutaneous injection of 12 ml of autologous hemolyzed blood clotted in situ, was made in 33 rats. Sventeen animals served as controls; the other 16 received daily intra-muscular injections of dexamethasone. After an initial decrease in size, 47% of the lesions in the control animals enlarged to a mean weight of 12.1 +/- 2.5 gm, while the lesions in the 16 steroid-treated rats weighted 3.2 +/- 0.70 gm (p less than 0.01). Histologically, lesions from the steroid group showed absence of neomembrane formation. These data offer further support to the theory that the neomembrane development and subsequent enlargement of subdural hematomas is due to inflammatory reactions of tissues in contact with large blood clots.
通过皮下注射12毫升原位凝结的自体溶血血液建立了先前描述的实验性血肿模型，该模型应用于33只大鼠。17只动物作为对照；另外16只每天接受肌肉注射地塞米松。在最初体积减小后，对照动物中47%的损伤扩大到平均重量为12.1±2.5克，而16只接受类固醇治疗的大鼠的损伤重量为3.2±0.70克（p<0.01）。组织学上，类固醇组的损伤显示无新膜形成。这些数据进一步支持了以下理论，即硬膜下血肿的新膜形成和随后的扩大是由于与大血凝块接触的组织的炎症反应所致。
