Peng Y M, Peng Y S, Childers J M, Hatch K D, Roe D J, Lin Y, Lin P
Arizona Cancer Center, University of Arizona, Tucson 85724, USA.
Cancer Epidemiol Biomarkers Prev. 1998 Apr;7(4):347-50.
Paired blood (collected after an overnight fast) and cervical tissue (cancerous, precancerous, and noncancerous) samples were obtained from 87 patients (age, 21-86 years) who had a hysterectomy or biopsy due to cervical cancer, precancer (cervical intraepithelial neoplasia I, II, and III), or noncancerous diseases. The samples were analyzed using high-performance liquid chromatography for 10 micronutrients (lutein, zeaxanthin, beta-cryptoxanthin, lycopene, alpha-carotene, beta-carotene, cis-beta-carotene, alpha-tocopherol, gamma-tocopherol, and retinol). The results indicated that: (a) among the three patient groups, the mean plasma concentrations of all micronutrients except gamma-tocopherol were lowest in the cancer patients; however, the mean tissue concentrations of the two tocopherols and certain carotenoids were highest in the cancerous tissue; and (b) among the 10 micronutrients, only the concentrations of beta-carotene and cis-beta-carotene were lower in both the plasma and tissue of cancer and precancer patients than in those of noncancer controls. These results suggest that: (a) not all of the micronutrient concentrations in plasma reflect the micronutrient concentrations in cervical tissue; thus, in some cases, it may be necessary to measure the tissue micronutrient concentrations to define the role of the micronutrients in cervical carcinogenesis; and (b) maintaining an adequate plasma and tissue concentration of beta-carotene may be necessary for the prevention of cervical cancer and precancer.
从87例患者（年龄21 - 86岁）获取配对的血液（空腹过夜后采集）和宫颈组织（癌组织、癌前组织和非癌组织）样本，这些患者因宫颈癌、癌前病变（宫颈上皮内瘤变I、II和III级）或非癌性疾病接受了子宫切除术或活检。使用高效液相色谱法分析样本中的10种微量营养素（叶黄素、玉米黄质、β - 隐黄质、番茄红素、α - 胡萝卜素、β - 胡萝卜素、顺式β - 胡萝卜素、α - 生育酚、γ - 生育酚和视黄醇）。结果表明：(a) 在三组患者中，除γ - 生育酚外，所有微量营养素的血浆平均浓度在癌症患者中最低；然而，两种生育酚和某些类胡萝卜素的组织平均浓度在癌组织中最高；(b) 在10种微量营养素中，只有β - 胡萝卜素和顺式β - 胡萝卜素在癌症和癌前病变患者的血浆和组织中的浓度低于非癌对照组。这些结果表明：(a) 并非血浆中的所有微量营养素浓度都反映宫颈组织中的微量营养素浓度；因此，在某些情况下，可能有必要测量组织微量营养素浓度以确定微量营养素在宫颈癌发生中的作用；(b) 维持足够的血浆和组织β - 胡萝卜素浓度可能对预防宫颈癌和癌前病变是必要的。
