Waldegger S, Steuer S, Risler T, Heidland A, Capasso G, Massry S, Lang F
Department of Physiology, University of Tübingen, Germany.
Nephrol Dial Transplant. 1998 Apr;13(4):867-74. doi: 10.1093/ndt/13.4.867.
A wide variety of factors challenge constancy of cell volume. Alterations of cell volume activate diverse cell volume regulatory mechanisms including ion transport, osmolyte accumulation, metabolism and expression of appropriate genes. A wealth of cellular signalling pathways link cell volume to the respective regulatory mechanisms. Cell volume emerges as a pathophysiologically important parameter in several diseases including diabetes mellitus, uraemia, hepatic insufficiency and hypercatabolic states. The role of altered cell volume in disease is a challenge which requires more experimental research and clinical investigation.
