Lewindon P J, Robb T A, Moore D J, Davidson G P, Martin A J
Gastroenterology Unit, Women's and Children's Hospital, North Adelaide, South Australia.
J Paediatr Child Health. 1998 Feb;34(1):79-82. doi: 10.1046/j.1440-1754.1998.00159.x.
To investigate the prevalence of carbohydrate malabsorption and bacterial overgrowth in children with cystic fibrosis (CF) and abnormal stool pattern referred for breath hydrogen testing.
Results from 89 tests using lactose, sucrose and lactulose in 54 children with CF were compared with 5430 tests on children with non-CF-related stool abnormalities.
Children with CF were more frequently unable to ferment lactulose to hydrogen (39% vs. 20%, P<0.03); they had significantly longer oro-caecal transit times (mean 99 vs. 68 min, P<0.0003); they had a higher incidence of bacterial overgrowth (32% vs. 7%, P<0.003) and sucrose malabsorption (47% vs. 14.5%, P<0.004); but they had no increase in lactose malabsorption (40% vs. 31%). Children with bacterial overgrowth in both groups had longer transit times (CF 123 min, non-CF 108 min) compared to the non-CF children without overgrowth (68 min) and reference normal children (69 min).
Bacterial overgrowth and carbohydrate malabsorption, particularly of sucrose, should be considered when assessing children with CF and abnormal stool patterns.
调查因粪便异常而接受呼气氢检测的囊性纤维化（CF）患儿碳水化合物吸收不良和细菌过度生长的发生率。
对54例CF患儿使用乳糖、蔗糖和乳果糖进行的89次检测结果，与5430例非CF相关粪便异常患儿的检测结果进行比较。
CF患儿更常无法将乳果糖发酵为氢气（39%对20%，P<0.03）；他们的口盲肠转运时间明显更长（平均99分钟对68分钟，P<0.0003）；他们的细菌过度生长（32%对7%，P<0.003）和蔗糖吸收不良（47%对14.5%，P<0.004）发生率更高；但乳糖吸收不良无增加（40%对31%）。与无细菌过度生长的非CF患儿（68分钟）和正常参考儿童（69分钟）相比，两组有细菌过度生长的患儿转运时间更长（CF组123分钟，非CF组108分钟）。
在评估有异常粪便的CF患儿时，应考虑细菌过度生长和碳水化合物吸收不良，尤其是蔗糖吸收不良。
