Rabin B, Nicolosi R J, Hayes K C
J Nutr. 1976 Sep;106(9):1241-6. doi: 10.1093/jn/106.9.1241.
Cats fed a semipurified diet containing casein as the source of protein develop taurine deficiency. In order to establish whether this had an adverse effect on bile, kittens and adult cats were fed the casein diet or that diet with a supplement of taurine, cystine, or methionine, and gall bladder bile was characterized for its taurine-glycine conjugation and the cholesterol: phospholipid: bile acid ratio. The data indicate that cats conjugate their bile acids almost exclusively with taurine, and though plasma and retinal pools of taurine are largely depleted by feeding the casein diet, the conjugation of bile acids is only moderately affected. A major conversion to glycine conjugation did not occur, but free cholic acid did increase with decreased taurine conjugation. Dietary supplements of methionine or cystine, precursors of taurine, failed to satisfy the taurine requirement for bile acids in kittens whereas methionine appeared to satisfy this requirement in adult cats. The cholesterol: phospholipid: bile acid profile was not appreciably altered by these dietary circumstances. It would appear that kittens may require dietary taurine and that taurine pools in cats may be biologically independent of one another.
喂食以酪蛋白为蛋白质来源的半纯化日粮的猫会出现牛磺酸缺乏。为了确定这是否会对胆汁产生不利影响，给小猫和成年猫喂食酪蛋白日粮或添加了牛磺酸、胱氨酸或蛋氨酸的该日粮，并对胆囊胆汁的牛磺酸 - 甘氨酸结合情况以及胆固醇：磷脂：胆汁酸比例进行了表征。数据表明，猫几乎完全将胆汁酸与牛磺酸结合，尽管喂食酪蛋白日粮会使血浆和视网膜中的牛磺酸池大量耗尽，但胆汁酸的结合仅受到中度影响。并未发生向甘氨酸结合的主要转变，但随着牛磺酸结合减少，游离胆酸确实增加。作为牛磺酸前体的蛋氨酸或胱氨酸的日粮补充未能满足小猫对胆汁酸的牛磺酸需求，而蛋氨酸似乎能满足成年猫的这一需求。这些日粮情况并未明显改变胆固醇：磷脂：胆汁酸谱。似乎小猫可能需要日粮中的牛磺酸，而且猫体内的牛磺酸池在生物学上可能彼此独立。
