Curran R C, McCann B G
J Pathol. 1976 Jul;119(3):135-46. doi: 10.1002/path.1711190303.
Nine benign pigmented naevi and 16 melanocarcinomas (malignant melanomas) were studied by light and transmission electron microscopy and the fine structure of benign and malignant melanocytes is described. It was found that malignant melanocytes generally exhibit a range of abnormalities of structure of nuclei and cytoplasmic organelles which distinguish them clearly from their benign counterparts. Of the abnormalities, those affecting the specific organelle of the melanocyte, the melanosome, were the most constantly present. No firm evidence was found for the existence of two types of melanosome or two types of melanocarcinoma. Although electron microscopy is capable of showing in great detail within individual melanocytes many changes which are clearly associated with malignancy, the technique does not appear to offer significant advantages over light microscopy in determining the diagnosis and prognosis in this group of conditions.
通过光学显微镜和透射电子显微镜对9个良性色素痣和16个黑色素瘤（恶性黑色素瘤）进行了研究，并描述了良性和恶性黑素细胞的精细结构。发现恶性黑素细胞通常表现出一系列细胞核和细胞质细胞器结构异常，这使其与良性黑素细胞明显区分开来。在这些异常中，影响黑素细胞特定细胞器黑素小体的异常最为常见。未发现存在两种类型黑素小体或两种类型黑色素瘤的确切证据。尽管电子显微镜能够非常详细地显示单个黑素细胞内许多与恶性相关的变化，但在确定这类疾病的诊断和预后方面，该技术似乎并不比光学显微镜具有显著优势。
