Sexton M, Sexton C W
Department of Pathology and Medicine, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey.
Arch Pathol Lab Med. 1991 Feb;115(2):122-6.
Melanocytic nevi that recur after incomplete removal are pigmented lesions that may clinically and pathologically simulate malignant melanoma in situ. Five examples of recurrent pigmented melanocytic nevus, with emphasis on light microscopic and immunohistochemical findings, are reported herein. Prominent HMB-45 staining in these nevi may cause further confusion in differentiating them from malignant melanoma. The differential diagnosis of recurrent pigmented melanocytic nevi is discussed, with particular emphasis on distinguishing these lesions from malignant melanoma. Our immunohistochemical observations indicate that the recurrences most likely develop as a result of proliferation of melanocytes remaining in the epidermis and/or adnexae following incomplete removal. The approach and management of recurrent nevi are also discussed.
切除不完全后复发的黑素细胞痣是色素性病变，在临床和病理上可能模拟原位恶性黑色素瘤。本文报告了5例复发性色素性黑素细胞痣，重点介绍了光镜和免疫组化结果。这些痣中显著的HMB-45染色可能会在将它们与恶性黑色素瘤区分开来时造成进一步混淆。讨论了复发性色素性黑素细胞痣的鉴别诊断，特别强调了将这些病变与恶性黑色素瘤区分开来。我们的免疫组化观察表明，复发很可能是由于切除不完全后表皮和/或附属器中残留的黑素细胞增殖所致。还讨论了复发性痣的处理方法和管理。
