Haraszti G, Kemény L, Bónis B, Dobozi A
Békés Megyei Képviselötestület Pándy Kálmán Kórháza Gyula, Börgyógyászati Osztály.
Orv Hetil. 1998 Apr 5;139(14):825-8.
Clinically it is impossible to make difference between the vulvar melanosis the harmless brown spotty change of the vulva and melanoma malignum, that is one of the most dangerous malignancies. Even the dermatoscopical examination was not efficient to exclude the melanoma surely. A small, representative biopsy was enough for the diagnosis, which has exempted the patient from the unjustified mutilating resections. On the patient's skin they detected also a few relatively small disseminated hypopigmented spots. Electronmicroscopically they could observe plenty of melanosomes and big melanosoma-complexes in the lower keratinocyte layers of the vulvar melanotic macules. Melanocytes could not be recognised in the hypopigmented spots.
临床上很难区分外阴黑变病（一种无害的外阴褐色斑点变化）和恶性黑色素瘤（最危险的恶性肿瘤之一）。即使是皮肤镜检查也无法肯定地排除黑色素瘤。一次小的、具有代表性的活检就足以确诊，这使患者免于不必要的致残性切除。在患者皮肤上还发现了一些相对较小的散在性色素减退斑。电子显微镜下，他们在外阴黑色素沉着斑的角质形成细胞下层观察到大量黑素小体和大的黑素体复合物。在色素减退斑中未发现黑素细胞。
