Dussault J H, Letarte J, Guyda H, Laberge C
J Pediatr. 1976 Oct;89(4):541-4. doi: 10.1016/s0022-3476(76)80382-4.
Various aspects of the thyroid function have been measured in 28 cases of neonatal hypothyroidism detected by means of the Quebec Screening Program for Metabolic Diseases. In all instances the T4 value in the blood of filter paper spot was below 2 SD of the mean of the day, averaging 0.39 +/- 0.04 ng/40 mul (mean +/- SEM) of eluted blood. The T4 value of a second similar sample averaged 0.22 +/- 0.04 ng/mul of eluted blood; this value was significantly lower than the first one. The serum T4 concentration was decreased in all the infants, whereas three of them had a normal serum TSH concentration. At least three groups of patients could be identified: (1) patients with primary thyroid failure, (2) those with secondary or tertiary hypothyrodism, and (3) those with abnormal synthesis of thyroid hormone.
通过魁北克代谢疾病筛查项目检测出28例新生儿甲状腺功能减退症，并对其甲状腺功能的各个方面进行了测量。在所有病例中，滤纸血斑中的T4值均低于当日均值的2个标准差，洗脱血平均为0.39±0.04 ng/40μl（均值±标准误）。第二个类似样本的T4值平均为0.22±0.04 ng/μl洗脱血；该值明显低于第一个值。所有婴儿的血清T4浓度均降低，其中3名婴儿的血清TSH浓度正常。至少可识别出三组患者：（1）原发性甲状腺功能减退患者，（2）继发性或三发性甲状腺功能减退患者，（3）甲状腺激素合成异常患者。
