Wang S L, Zhao Z T, Li J, Zhu X Z, Dong H, Zhang Y G
Salivary Gland Disease Center, Beijing Hospital for Stomatology, Capital University of Medical Sciences, P. R. China.
Arch Oral Biol. 1998 Jan;43(1):39-43. doi: 10.1016/s0003-9969(97)00092-7.
The symptom of dry mouth was correlated with unstimulated (UWSFR) and stimulated (SWSFR) whole-saliva flow rate on chewing medical paraffin in 62 patients with dry-mouth complaints (30 with Sjögren's syndrome, 32 with sialosis) and 23 controls. The symptom of dry mouth was classified into grades 0,1,2,3,4 according to a Treatment Emergent Symptom Scale (TESS). UWSFR and SWSFR were determined after fasting in the morning. UWSFR was 0.070 +/- 0.089 ml/min in Sjögren's syndrome, 0.175 +/- 0.115 ml/min in sialosis, 0.330 +/- 0.188 ml/min in controls. SWSFR was 0.709 +/- 0.720 ml/min in Sjögren's syndrome, 1.561 +/- 0.867 ml/min in sialosis, 1.894 +/- 0.661 ml/min in controls. A highly significant correlation was found between TESS score and UWSFR and between TESS score and SWSFR. Only UWSFR was decreased in the patients with a TESS score of 1 or 2, while both UWSFR and SWSFR were significantly decreased in the patients with TESS scores of 3, 4. It is concluded that UWSFR is more sensitive in relation to dry-mouth complaints than SWSFR, and that a mild dry mouth is mainly related to decreased UWSFR.
在62例有口干主诉的患者（30例干燥综合征患者、32例涎腺肿大患者）及23名对照者中，咀嚼医用石蜡时的口干症状与非刺激性（UWSFR）和刺激性（SWSFR）全唾液流速相关。根据治疗突发症状量表（TESS），将口干症状分为0、1、2、3、4级。于早晨空腹后测定UWSFR和SWSFR。干燥综合征患者的UWSFR为0.070±0.089 ml/分钟，涎腺肿大患者为0.175±0.115 ml/分钟，对照者为0.33±0.188 ml/分钟。干燥综合征患者的SWSFR为0.709±0.720 ml/分钟，涎腺肿大患者为1.561±0.867 ml/分钟，对照者为1.894±0.661 ml/分钟。发现TESS评分与UWSFR之间以及TESS评分与SWSFR之间存在高度显著相关性。TESS评分为1或2的患者仅UWSFR降低，而TESS评分为3、4的患者UWSFR和SWSFR均显著降低。结论是，与SWSFR相比，UWSFR对口干主诉更敏感，轻度口干主要与UWSFR降低有关。
