Drew J H, Kitchen W H
J Pediatr. 1976 Oct;89(4):657-61. doi: 10.1016/s0022-3476(76)80413-1.
The effects of drugs administered to pregnant women on bilirubin concentrations in 1,107 consecutively born infants are presented. Administration of narcotic agents, barbiturates, aspirin, chloral hydrate, reserpine, and phenytoin sodium all resulted in lowering of infant serum bilirubin concentrations. Diazepam and, to a lesser extent, oxytocin caused an elevation of infant serum bilirubin concentrations. Although many drugs were shown to alter serum bilirubin levels significantly, the clinical importance of such alterations was not dramatic except possibly in special circumstances. The phenothiazine derivatives, general or local anesthesia, sulfadimidine, ampicillin, and penicillin had no such effect on the newborn infant when given to the mother before delivery.
本文介绍了对1107名连续出生的婴儿，孕妇用药对其胆红素浓度的影响。给予麻醉剂、巴比妥类药物、阿司匹林、水合氯醛、利血平和苯妥英钠均导致婴儿血清胆红素浓度降低。地西泮以及程度较轻的缩宫素会导致婴儿血清胆红素浓度升高。尽管许多药物被证明能显著改变血清胆红素水平，但除了在特殊情况下，这种改变的临床意义并不显著。吩噻嗪衍生物、全身或局部麻醉、磺胺二甲嘧啶、氨苄西林和青霉素在分娩前给予母亲时，对新生儿没有这样的影响。
