Drew J H, Barrie J, Horacek I, Kitchen W H
Arch Dis Child. 1978 Jan;53(1):49-52. doi: 10.1136/adc.53.1.49.
A study of 887 consecutively born immigrant Greek and 220 Anglo-Saxon Australian infants has shown that serum bilirubin concentrations are influenced by these factors: breast feeding, delivery with forceps, gestation, birthweight, sex of the infant, presence of hypoxia, presence of blood group incompatibility, a positive direct Coombs's test, maternal sepis, and administration to the mother of promethazine hydrochloride, reserpine, chloral hydrate, barbiturates, narcotic agents, diazepam, oxytocin, aspirin, and phenytoin sodium. Apart from the administration of promethazine hydrochloride, reserpine, chloral hydrate, and quinalbarbitone sodium, only two factors, breast feeding and delivery by forceps, occured with different frequencies in the immigrant Greek and the Australian infants. Among the Greek infants with jaundice, there were few where the cause of the jaundice was inapparent. The immigrant Greek and Australian newborn populations were therefore remarkably similar. Since differences of frequency and severity of jaundice do exist in infants born in Greece, this difference must be lost when the parents emigrate, and therefore an environmental factor must be incriminated as the causative agent for jaundice of unknown origin in Greece.
一项针对887名希腊移民和220名澳大利亚盎格鲁 - 撒克逊裔连续出生婴儿的研究表明，血清胆红素浓度受以下因素影响：母乳喂养、产钳助产、孕周、出生体重、婴儿性别、是否存在缺氧、是否存在血型不合、直接抗人球蛋白试验阳性、母亲败血症以及母亲是否使用盐酸异丙嗪、利血平、水合氯醛、巴比妥类药物、麻醉剂、地西泮、缩宫素、阿司匹林和苯妥英钠。除了盐酸异丙嗪、利血平、水合氯醛和硫喷妥钠的使用外，只有母乳喂养和产钳助产这两个因素在希腊移民婴儿和澳大利亚婴儿中的出现频率不同。在患有黄疸的希腊婴儿中，黄疸原因不明显的情况很少。因此，希腊移民和澳大利亚新生儿群体非常相似。由于在希腊出生的婴儿中确实存在黄疸频率和严重程度的差异，当父母移民时这种差异必定消失，所以必须将环境因素认定为希腊不明原因黄疸的致病因素。
