Sun Y P, Zhu B Q, Sievers R E, Norkus E P, Parmley W W, Deedwania P C
Department of Medicine and Cardiovascular Research Institute, University of California, San Francisco 94143-0124, USA.
Cardiology. 1998 Mar;89(3):189-94. doi: 10.1159/000006786.
Antioxidant vitamins are hypothesized to help prevent atherosclerosis by blocking lipoprotein oxidation. We investigated the effects of dietary vitamins C and E on atherosclerosis in rabbits.
Forty New Zealand male rabbits were divided into 4 groups: 0.3% cholesterol diet with (LV) and without vitamin (LC), and 0.5% cholesterol diet with (HV) and without vitamins (HC). The treated groups consumed 137 +/- 8 mg/day vitamin C and 80 +/- 4 mg/day vitamin E for 10 weeks. Vitamin treatment did not significantly affect serum lipids. Alpha-tocopherol values were significantly higher in both serum (mg/dl) and omental fat (microg/g) among the treated rabbits (3.9 +/- 0.5 and 31.6 +/- 2.1 for LV, 1.7 +/- 0.2 and 12.1 +/- 1.9 for LC, 5.6 +/- 0.8 and 51.3 +/- 9.3 for HV and 1.9 +/- 0.3 and 8.2 +/- 0.4 for HC; p < 0.001). Vitamin treatment did not affect the percent of surface lesions in the aorta and pulmonary artery (23.8 +/- 5.2 and 20.1 +/- 3.3% for LV, 19.8 +/- 5.6 and 23.2 +/- 3.5% for LC, 28.1 +/- 6.5 and 51.1 +/- 4.2% for HV and 32.4 +/- 5.5 and 43.7 +/- 3.9% for HC, respectively; p = 0.981 and p = 0.562.
Although significantly higher values of alpha-tocopherol were found in both serum and omental fat, antioxidant vitamins C and E did not demonstrate a significant protective effect on atherosclerosis in lipid-fed rabbits during the 10-week study period.
抗氧化维生素被认为可通过阻止脂蛋白氧化来预防动脉粥样硬化。我们研究了膳食维生素C和E对兔动脉粥样硬化的影响。
40只新西兰雄性兔被分为4组：含0.3%胆固醇饮食且补充维生素（LV）组、含0.3%胆固醇饮食不补充维生素（LC）组、含0.5%胆固醇饮食且补充维生素（HV）组和含0.5%胆固醇饮食不补充维生素（HC）组。治疗组连续10周每日摄入137±8毫克维生素C和80±4毫克维生素E。维生素治疗对血清脂质无显著影响。治疗兔血清（毫克/分升）和网膜脂肪（微克/克）中的α-生育酚值均显著更高（LV组分别为3.9±0.5和31.6±2.1，LC组分别为1.7±0.2和12.1±1.9，HV组分别为5.6±0.8和51.3±9.3，HC组分别为1.9±0.3和8.2±0.4；p<0.001）。维生素治疗对主动脉和肺动脉表面病变百分比无影响（LV组分别为23.8±5.2%和20.1±3.3%，LC组分别为19.8±5.6%和23.2±3.5%，HV组分别为28.1±6.5%和51.1±4.2%，HC组分别为32.4±5.5%和43.7±3.9%；p = 0.981和p = 0.562）。
尽管血清和网膜脂肪中的α-生育酚值显著更高，但在为期10周的研究期间，抗氧化维生素C和E对高脂喂养兔的动脉粥样硬化未显示出显著的保护作用。
