Henricks P A, Nijkamp F P
Department of Pharmacology and Pathophysiology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Netherlands.
Eur J Pharmacol. 1998 Feb 26;344(1):1-13. doi: 10.1016/s0014-2999(98)00036-3.
Cell adhesion molecules mediate the contact between two cells or between cells and the extracellular matrix. They are essential for morphogenesis, organization of tissues and organs, regulation of immune cell responses and migration of inflammatory cells from the blood vessels into inflamed tissues. Many diseases have been shown to be associated with dysfunction or with overexpression of certain adhesion molecules. Increased cell adhesion molecule function and number are found in clinical disorders in which inflammation and immune cells are involved. Several possible therapeutic agents are described here which have been shown to reduce the expression and/or function of cell adhesion molecules. Anti-adhesion treatment can lead to diminished infiltration and activation of inflammatory immune cells resulting in decreased tissue injury and malfunction.
细胞黏附分子介导两个细胞之间或细胞与细胞外基质之间的接触。它们对于形态发生、组织和器官的构建、免疫细胞反应的调节以及炎症细胞从血管迁移到炎症组织中至关重要。许多疾病已被证明与某些黏附分子的功能障碍或过度表达有关。在涉及炎症和免疫细胞的临床疾病中发现细胞黏附分子的功能和数量增加。本文描述了几种已被证明可降低细胞黏附分子表达和/或功能的可能治疗药物。抗黏附治疗可导致炎症免疫细胞的浸润和活化减少，从而减少组织损伤和功能障碍。
