Arnaout M A
Department of Medicine, Massachusetts General Hospital, Charlestown 02129.
Am J Kidney Dis. 1993 Jan;21(1):72-6. doi: 10.1016/s0272-6386(12)80725-6.
Cell-cell and cell-matrix interactions play vital roles in morphogenesis, inflammation, thrombosis, wound healing, immune surveillance, and growth and metastasis. A number of cell surface receptors, so-called cell adhesion molecules (CAMs), mediate these events in various cell types. In leukocytes and platelets, several CAM families interact with each other or with the extracellular matrix in a well-orchestrated manner, to bring these circulating cells to areas of antigenic challenge and tissue injury. Significant progress has been made recently in understanding the molecular basis of leukocyte recruitment into tissues and the formation of the hemostatic plug. Several murine or humanized monoclonal antibodies directed against key adhesion receptors that mediate these events have been found effective in taming immune and thrombotic injury in experimental animal models and in phase I clinical trials. These advances herald the arrival of a novel class of antiinflammatory and antithrombotic drugs, the antiadhesions, which will likely be effective in many clinical situations facing the nephrologist and internist.
细胞间和细胞与基质间的相互作用在形态发生、炎症、血栓形成、伤口愈合、免疫监视以及生长和转移过程中发挥着至关重要的作用。许多细胞表面受体，即所谓的细胞粘附分子（CAMs），在各种细胞类型中介导这些事件。在白细胞和血小板中，几个CAM家族以精心编排的方式相互作用或与细胞外基质相互作用，将这些循环细胞带到抗原攻击和组织损伤的部位。最近在理解白细胞募集到组织中的分子基础以及止血栓的形成方面取得了重大进展。已经发现几种针对介导这些事件的关键粘附受体的鼠源或人源化单克隆抗体在实验动物模型和I期临床试验中对于控制免疫和血栓形成损伤有效。这些进展预示着一类新型抗炎和抗血栓药物——抗粘附药物的到来，这类药物可能在肾脏病学家和内科医生面临的许多临床情况下有效。
