Lysaker P H, Bell M D, Bryson G, Kaplan E
Hamilton Center Inc., Linton, Indiana 47441, USA.
Acta Psychiatr Scand. 1998 Apr;97(4):297-301. doi: 10.1111/j.1600-0447.1998.tb10003.x.
It remains unclear how impaired insight and neurocognitive impairment are related to one another in schizophrenia. In order to examine this relationship, subjects with schizophrenia or schizoaffective disorder were classified as having 'impaired' (n=38) or 'unimpaired' (n=43) insight based on their insight rating on the Positive and Negative Syndrome Scale (PANSS). Their performance on neuropsychological tests of global function, executive function, memory and vigilance was then compared. Multivariate analyses followed by Scheffe tests indicated that subjects with impaired insight performed less well on the Wisconsin Card Sorting Test, demonstrating poorer abstract flexibility and heightened perseveration. No differences were found between the groups with regard to global cognitive function, memory or vigilance. This suggests that insight is closely linked to deficits in executive function, and that it may be associated with the compromise of frontal lobe function.
在精神分裂症中，洞察力受损与神经认知障碍之间的关系仍不清楚。为了研究这种关系，根据精神分裂症或分裂情感性障碍患者在阳性和阴性症状量表（PANSS）上的洞察力评分，将他们分为“洞察力受损”组（n = 38）和“洞察力未受损”组（n = 43）。然后比较两组在整体功能、执行功能、记忆和警觉性的神经心理学测试中的表现。多变量分析及随后的谢费检验表明，洞察力受损的受试者在威斯康星卡片分类测试中的表现较差，表现出较差的抽象灵活性和更强的持续性。两组在整体认知功能、记忆或警觉性方面未发现差异。这表明洞察力与执行功能缺陷密切相关，并且可能与额叶功能受损有关。
