丙型肝炎相关性冷球蛋白血症患者接受α-干扰素治疗期间血管炎急性加重
Acute exacerbation of vasculitis during interferon-alpha therapy for hepatitis C-associated cryoglobulinaemia.
作者信息
Gordon A C, Edgar J D, Finch R G
机构信息
Department of Microbiology and Infectious Diseases, Nottingham City Hospital, UK.
出版信息
J Infect. 1998 Mar;36(2):229-30. doi: 10.1016/s0163-4453(98)80022-4.
PMID:9570663
Abstract
A significant, previously unreported, adverse reaction to interferon-alpha therapy is reported. Immediately after the commencement of low dose therapy a man with hepatitis-C associated cryoglobulinaemia developed a purpuric rash and a severe, reversible impairment of renal function. This observation may elucidate the immunopathogenesis of vasculitis.
摘要
据报道，α干扰素治疗出现了一种显著的、此前未报告的不良反应。一名患有丙型肝炎相关性冷球蛋白血症的男性在低剂量治疗开始后不久，出现了紫癜性皮疹和严重的、可逆转的肾功能损害。这一观察结果可能有助于阐明血管炎的免疫发病机制。
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