O'Brien J E, Hinsvark O N
J Pharm Sci. 1976 Jul;65(7):1068-9. doi: 10.1002/jps.2600650730.
A procedure is described for extracting doxepin, a tricyclic antidepressant, from plasma and subsequently measuring its concentration by GLC. The developed technique permits the resolution and quantitative determination of the cis- and trans-isomers of doxepin as well as its desmethyl metabolite. The method allows precise, reliable measurement of the drug and one of its metabolities in concentrations as low as 10 ng/ml of plasma.
本文描述了一种从血浆中提取三环类抗抑郁药多塞平并随后通过气相色谱法测量其浓度的方法。所开发的技术能够分离并定量测定多塞平的顺式和反式异构体及其去甲基代谢物。该方法能够精确、可靠地测量血浆中低至10纳克/毫升浓度的药物及其一种代谢物。
