Racine R, Burnham W M, Livingston K
Department of Psychology, McMaster University, Hamilton, Ont., Canada.
Electroencephalogr Clin Neurophysiol. 1979 Aug;47(2):204-12. doi: 10.1016/0013-4694(79)90221-9.
The effects of cortically kindled seizure responses of procaine hydrochloride, diazepam and combinations of these two drugs were tested in this study. The cortex was stimulated until seizure responses developed past the focal stage (accompanied primarily by brief tonic convulsions) to the cortico-generalized stage (accompanied, typically, by an early brief tonus followed by a longer clonic seizure that is characteristic of subcortically triggered seizures). Diazepam was found to block the generalized component of the cortico-generalized electrographic and motor seizure leaving the tonus only slightly suppressed. Procaine blocked the tonus leaving the clonic seizure and discharge that is characteristic of the generalized response relatively intact. Combinations of half doses of the two drugs completely blocked all electrographic and motor seizure responses in about half the animals. The remaining animals had a very brief discharge with no convulsive responses.
本研究测试了盐酸普鲁卡因、地西泮以及这两种药物组合对皮层点燃癫痫反应的影响。刺激皮层直至癫痫反应从局灶性阶段（主要伴有短暂的强直性惊厥）发展到皮层全身性阶段（典型表现为早期短暂的强直，随后是较长时间的阵挛性癫痫发作，这是皮层下触发癫痫发作的特征）。结果发现，地西泮可阻断皮层全身性脑电图和运动性癫痫发作的全身性成分，仅使强直略有抑制。普鲁卡因可阻断强直，使阵挛性癫痫发作和全身性反应特有的放电相对保持完整。两种药物半量组合在约一半的动物中完全阻断了所有脑电图和运动性癫痫反应。其余动物有非常短暂的放电，但无惊厥反应。
