Pinel J P
Pharmacol Biochem Behav. 1983 Jan;18(1):61-3. doi: 10.1016/0091-3057(83)90252-6.
Diazepam (1 mg/kg) was more effective than diphenylhydantoin (100 mg/kg) in suppressing motor seizures elicited in kindled rats by amygdaloid stimulation; however, the effect of these drugs on the incidence of spontaneous motor seizures in rats kindled by amygdaloid stimulation was just the opposite. At the same doses, diphenylhydantoin effectively suppressed spontaneous motor seizures, but diazepam did not. This double dissociation suggests the need for caution in drawing inferences concerning spontaneously recurring seizures from studies of elicited seizures.
地西泮（1毫克/千克）在抑制杏仁核刺激诱发的点燃大鼠运动性癫痫发作方面比苯妥英（100毫克/千克）更有效；然而，这些药物对杏仁核刺激点燃的大鼠自发性运动性癫痫发作发生率的影响却恰恰相反。在相同剂量下，苯妥英能有效抑制自发性运动性癫痫发作，而地西泮则不能。这种双重解离表明，在从诱发性癫痫发作的研究中推断自发性复发性癫痫发作时需要谨慎。
