Vehmas T, Markkola A T
Department of Radiology, Helsinki University Central Hospital, Finland.
Acta Radiol. 1998 May;39(3):223-6. doi: 10.1080/02841859809172184.
Patients with contra-indications to iodine-based contrast media present problems in radiological examination. In this study, we evaluated Gd-DTPA as an alternative contrast agent in conventional and interventional radiology.
The undiluted contrast agent Gd-DTPA meglumine (469 mg/ml, Magnevist) was used in 10 examinations in 8 patients. A dosage of 20-45 ml was used in 5 conventional studies: endoscopic retrograde cholangiography, cystography, urethrocystography, and 2 retrograde pyelographies. A dosage of 10-120 ml was used in 5 interventions: 1 percutaneous nephrostomy, and 4 biliary tract drainages.
The image quality was adequate in all studies. No adverse pharmacological reactions occurred; however, there was renal extravasation of Gd-DTPA which did cause temporary pain in 1 patient at bilateral retrograde pyelography.
Gd-DTPA may be used as an alternative contrast medium in selected conventional and interventional roentgenological studies when iodine is contra-indicated.
对碘造影剂有禁忌证的患者在放射检查中存在问题。在本研究中，我们评估了钆喷酸葡胺作为传统放射学和介入放射学中替代造影剂的情况。
8例患者的10次检查中使用了未稀释的造影剂钆喷酸葡胺葡甲胺（469mg/ml，马根维显）。5项传统检查（内镜逆行胆管造影、膀胱造影、尿道膀胱造影和2次逆行肾盂造影）中使用剂量为20 - 45ml。5项介入操作（1次经皮肾造瘘术和4次胆道引流）中使用剂量为10 - 120ml。
所有检查中图像质量均足够。未发生不良药物反应；然而，钆喷酸葡胺有肾外渗情况，在1例患者双侧逆行肾盂造影时确实引起了短暂疼痛。
当碘造影剂禁忌时，钆喷酸葡胺可作为某些传统和介入放射学检查中的替代造影剂。
