Crippens D, Robinson T E
Department of Psychology, University of Michigan, Ann Arbor 48104-1687.
Brain Res. 1994 Jul 4;650(1):56-62. doi: 10.1016/0006-8993(94)90206-2.
The effect of withdrawal from chronic morphine or amphetamine treatment on dopamine (DA) neurotransmission in the ventral-medial striatum was studied by use of in vivo microdialysis. There was no effect of 24 h of amphetamine withdrawal on the basal concentration of DA in the ventral-medial striatum. Spontaneous morphine withdrawal (24 h) was associated with a significant decrease in the basal concentration of DA in dialysate, but following morphine replacement and naloxone-precipitated withdrawal variations in withdrawal symptoms were not related to variations in the concentration of DA in dialysate. It is suggested that: (1) the correlation between the extracellular concentration of DA in the ventral-medial striatum and the symptoms of morphine withdrawal may not be indicative of a necessary, causal relationship; and (2) a decrease in the extracellular concentration of DA in the ventral-medial striatum is not a common feature of drug withdrawal syndromes.
通过体内微透析研究了慢性吗啡或苯丙胺治疗戒断对腹内侧纹状体中多巴胺（DA）神经传递的影响。24小时的苯丙胺戒断对腹内侧纹状体中DA的基础浓度没有影响。自发吗啡戒断（24小时）与透析液中DA基础浓度的显著降低有关，但在吗啡替代和纳洛酮诱发戒断后，戒断症状的变化与透析液中DA浓度的变化无关。研究表明：（1）腹内侧纹状体中DA细胞外浓度与吗啡戒断症状之间的相关性可能并不表明存在必然的因果关系；（2）腹内侧纹状体中DA细胞外浓度降低并非药物戒断综合征的共同特征。
